The axis are rotating in opposite directions which allows the rapid and homogenous mixing of materials. The SpeedMixer™ DAC 150.1 FV is a centrifuge with two rotating axis in laboratory-size. The obtained protein melting temperature and other thermodynamic parameters are indicative for the thermal stability of the protein.Ī high thermal stability is beneficial for the development of therapeutic protein drugs. Microcalorimetry is the gold standard method for thermal analysis of liquid protein formulations. Used for monolayer formation and surface pressure measurements, as well as for creation and transfer of films to solid surfaces using Langmuir-Blodgett or Langmuir-Schaefer deposition technique. Lyophilization is often used in terms of biopharmaceuticals, which are prone to denature or aggregate in a liquid formulation.Ĭharacterization of amphiphilic molecules at the air-water interface. Most common process for making solid protein pharmaceuticals. UV and RI Detectors for the determination of drug or protein concentration. PN3609 Multi-Angle Light Scattering Detector for a precise and robust determination of molar mass and particle size. Temperature controlled jacket and valve package for non-stop continuous flow.įT-IR Spectrometer Bruker Tensor 27 IR Spectrometer with Hyperion microscope (Bruker Optics)ĭetermination of protein secondary structure by Fourier transform infrared spectroscopy.ĪTR objective (20x) for the Hyperion microscope combines a visual sample inspection with highest sensitivity of the IR measurement.ĪF2000 MultiFlow FFF (Postnova Analytics)Īsymmetrical flow field-flow fractionation (AF4) Platform for Separation of Proteins, Macromolecules and Nanoparticles. Mixing of two fluids at high pressure and flow rate up to 50 ml/minute. Particle size measurements in aqueous media as well as in oily suspensions.ĭual-syringe-pump 100DX system (Teledyne Isco) Laser diffraction particle size distribution analysis (submicron and micrometer range). LA-950 Laser Particle Size Analyzer (Horiba) Key instrument to track the residual moisture in spray- dried or lyophilized formulations.
Malvern zetasizer nano ph titration free#
Headspace Karl- Fischer- Titrator (Analytik Jena):ĭetemination of chemically bounded and free water in materials (water range: 0.01- 100 mg). Particle size measurement by dynamic light scattering (nanometer to low micrometer range).Īnalysis of zeta potential and electrophoretic mobility using electrophoretic light scattering. Viscosity is a key parameter for high concentrated protein formulations or polymer solutions. For viscosity measurement with a low volume consumption (V = 50- 100 µl).
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